Miguel-Aliaga LabGut Signalling and Metabolism


Key publications

  • Hadjieconomou D, King G, Gaspar P, Mineo A, Blackie L, Ameku T, Studd C, de Mendoza A, Diao F, White BH, Brown AEX, Plaçais P-Y, Préat T and Miguel-Aliaga I (2020)

    Enteric neurons increase maternal food intake during reproduction. Nature 587(7834):455-459.

  • Redhai S, Pilgrim C, Gaspar P, van Giesen L, Lopes T, Riabinina O, Grenier T, Milona A, Chanana B, Swadling JB, Wang Y-F, Dahalan F, Yuan M, Wilsch-Brauninger M, Lin W-H, Dennison N, Capriotti P, Lawniczak MKN, Baines RA, Warnecke T, Windbichler N, Leulier F, Bellono NW and Miguel-Aliaga I (2020)

    An intestinal zinc sensor regulates food intake and developmental growth. Nature 580(7802):263-268.

  • Hudry B, de Goeij E, Mineo A, Gaspar P, Hadjieconomou D, Studd C, Mokochinski JB, Kramer HB, Plaçais P-Y, Preat T and Miguel-Aliaga I (2019)

    Sex differences in intestinal carbohydrate metabolism promote food intake and sperm maturation. Cell 178(4):901-918.

  • Hudry B, Khadayate S and Miguel-Aliaga I (2016)

    The sexual identity of adult intestinal stem cells controls organ size and plasticity. Nature 530, 344–348.

  • Reiff T, Jacobson J, Cognigni P, Antonello Z, Ballesta E, Tan KJ, Yew JY, Dominguez M and Miguel-Aliaga I (2015)

    Endocrine remodelling of the adult intestine sustains reproduction in Drosophila. eLife 4, e06930.

  • Linneweber GA, Jacobson J, Busch KE, Hudry B, Christov CP, Dormann D, Yuan M, Otani T, Knust E, de Bono M and Miguel-Aliaga I (2014)

    Neuronal control of metabolism through nutrient-dependent modulation of tracheal branching. Cell 156, 69-83.

Other publications

  • Miguel-Aliaga I (2022)

    Let’s talk about (biological) sex. Nat Rev Mol Cell Biol 23(4):227-228.

  • Mineo A, Miguel-Aliaga I (2021)

    Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff. Cell Metab 7;33(12):2307-230.

  • Hiiragi T, Gladfelter AS, Miguel-Aliaga I, Coller HA, Lau OS, McBride HM, Aoki K, Linkermann A, Santaguida S, Wasteneys G, Rivron NC, Shahbazi MN, Ebisuya M, Lancaster MA (2021)

    20 years of Developmental Cell: Looking forward. Dev Cell 6;56(23):3185-3191.

  • Wang Y, Blackie L, Miguel-Aliaga I, Bai W (2022)

    Memory-efficient segmentation of high-resolution volumetric microCT images. Proc Mach Learn Res, accepted.

  • Kim SK, Tsao DD, Suh GSB, Miguel-Aliaga I (2021)

    Discovering signaling mechanisms governing metabolism and metabolic disease with Drosophila. Cell Metab, 6 (7):1279-1292.

  • Imambocus BN, Zhou F, Formozov A, Wittich A, Tenedini F, Hu C, Sauter K, Macarenhas Varela E, Herédia F, Casimiro AP, Macedo A, Schlegel P, Yang C-H, Miguel-Aliaga I, Wiegert JS, Pankratz MJ, Gontijo AM, Cardona A, Soba P (2021)

    A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. Curr Biol 10;32(1):149-163.e8.

  • Cable J, Pourquié O, Wellen KE, Finley LWS, Aulehla A, Gould AP, Teleman A, Tu WB, Garrett WS, Miguel-Aliaga I, Perrimon N, Hooper LV, Walhout AJM, Wei W, Alexandrov T, Erez A, Ralser M, Rabinowitz JD, Hemalatha A, Gutiérrez-Pérez P, Chandel NS, Rutter J, Locasale JW, Landoni JC, Christofk H (2021)

    Metabolic decisions in development and disease-a Keystone Symposia report. Ann N Y Acad Sci, Aug 19. Online ahead of print.

  • Millington JW, Brownrigg GP, Chao C, Sun Z, Basner-Collins PJ, Wat LW, Hudry B, Miguel-Aliaga I, Rideout EJ (2021)

    Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity. Elife 10:e58341.

  • Messal HA, Almagro J, Thin MZ, Tedeschi A, Ciccarelli A, Blackie L, Anderson KI, Miguel-Aliaga I, van Rheenen J and Behrens A (2021)

    Antigen retrieval and 1 clearing for whole organ immunofluorescence by FLASH. Nat Protoc 16(1):239-262.

  • Brown K (2020)

    An interview with Irene Miguel-Aliaga. Development 147(11):dev191650.

  • Ameku T, Beckwith H, Blackie L and Miguel-Aliaga I (2020)

    Food, microbes, sex and old age: on the plasticity of gastrointestinal innervation. Current Opin Neurobiol 62:83-91.

  • Milona A, Massafra V, Vos H, Naik J, Artigas N, Paterson HAB, Bijsmans ITGW, Willemsen ECL, Ramos Pittol JM, Miguel-Aliaga I, Bosma P, Burgering BMT, Williamson C, Vernia S, Dhillo WS, van Mil SWC and Owen BM (2019)

    Steroidogenic control of liver metabolism through a nuclear receptor-network. Mol Metab 30:221-229.

  • Miguel-Aliaga I, Jasper H and Lemaitre B (2018)

    Anatomy and physiology of the digestive tract of Drosophila melanogaster. Genetics 210(2), 357-396.

  • Grmai L, Hudry B, Miguel-Aliaga I and Bach EA (2018)

    Chinmo prevents transformer alternative splicing to maintain male sex identity. PLOS Genet 14(2):e1007203.

  • Irene Miguel-Aliaga (2017)

    Q&A: Irene Miguel-Aliaga. Current Biology 27, R286-R287.

  • Perea D, Guiu J, Hudry B, Konstantinidou C, Milona A, Hadjieconomou D, Carroll T, Hoyer N, Natarajan D, Kallijärvi J, Walker JA, Soba P, Thapar N, Burns AJ, Jensen KB and Miguel-Aliaga I (2017)

    Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia. 36(20), 3029-3045. 

  • Soba P, Han C, Zheng Y, Perea D, Miguel-Aliaga I, Jan LY and Jan YN (2015)

    The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion. eLife 4, e05491.

  • Miguel-Aliaga I and Bobrowska A (2015)

    Cell scientist to watch--Irene Miguel-Aliaga. Journal of Cell Science 128, 3519-20.

  • Wayland MT, Defaye A, Rocha J, Jayaram SA, Royet J, Miguel-Aliaga I, Leulier F and Cognigni P (2014)

    Spotting the differences: Probing host/microbiota interactions with a dedicated software tool for the analysis of faecal outputs in Drosophila. Journal of insect physiology 69, 126-135.

  • Martorell O, Merlos-Suarez A, Campbell K, Barriga FM, Christov CP, Miguel-Aliaga I, Batlle E, Casanova J and Casali A (2014)

    Conserved mechanisms of tumorigenesis in the Drosophila adult midgut. PloS one 9, e88413.

  • Lemaitre B and Miguel-Aliaga I (2013)

    The Digestive Tract of Drosophila melanogaster. Annual Review of Genetics 47, 377-404.

  • Sarraf-Zadeh L, Christen S, Sauer U, Cognigni P, Miguel-Aliaga I, Stocker H, Kohler K and Hafen E (2013)

    Local requirement of the Drosophila insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions. Developmental biology 381, 97-106.

  • Talsma A, Christov CP, Terriente-Felix A, Linneweber G, Perea D, Wayland M, Shafer OT and Miguel-Aliaga I (2012)

    Remote control of renal function by the intestinal neuropeptide pigment-dispersing factor in Drosophila. Proceedings of the National Academy of Sciences of the United States of America 109, 12177-12182.

  • Miguel-Aliaga I, Oliver B and Teleman AA (2012)

    The flies of Icarus: science with wings in Crete. EMBO reports 13, 945-947.

  • Miguel-Aliaga I (2012)

    Nerveless and gutsy: intestinal nutrient sensing from invertebrates to humans. Seminars in cell & developmental biology 23, 614-620.

  • Oyallon J, Apitz H, Miguel-Aliaga I, Timofeev K, Ferreira L and Salecker I (2012)

    Regulation of locomotion and motoneuron trajectory selection and targeting by the Drosophila homolog of Olig family transcription factors. Developmental biology 369, 261-276.

  • Cognigni P, Bailey AP and Miguel-Aliaga I (2011)

    Enteric neurons and systemic signals couple nutritional and reproductive state with intestinal homeostasis. Cell Metabolism 13, 92-104.

  • Suska A, Miguel-Aliaga I and Thor S (2011)

    Segment-specific generation of Drosophila Capability neuropeptide neurons by multi-faceted Hox cues. Developmental biology 353, 72-80.

  • Pulver SR, Cognigni P, Denholm B, Fabre C, Gu WX, Linneweber G, Prieto-Godino L, Urbancic V, Zwart M and Miguel-Aliaga I (2011)

    Why flies? Inexpensive public engagement exercises to explain the value of basic biomedical research on Drosophila melanogaster. Advances in physiology education 35, 384-392.

  • Miguel-Aliaga I and Thor S (2009)

    Programmed cell death in the nervous system--a programmed cell fate? Current opinion in neurobiology 19, 127-133.

  • Miguel-Aliaga I, Thor S and Gould AP (2008)

    Postmitotic specification of Drosophila insulinergic neurons from pioneer neurons. PLoS biology 6, e58.

  • Bardet PL, Kolaghar G, Mynett A, Miguel-Aliaga I, Briscoe J, Meier P and Vincent JP (2008)

    A fluorescent reporter of caspase activity for live imaging. Proceedings of the National Academy of Sciences of the United States of America 105, 13901-13905.

  • Baumgardt M, Miguel-Aliaga I, Karlsson D, Ekman H and Thor S (2007)

    Specification of neuronal identities by feedforward combinatorial coding. PLoS Biology 5, e37.

  • Sheldon TJ, Miguel-Aliaga I, Gould AP, Taylor WR and Conklin D (2007)

    A novel family of single VWC-domain proteins in invertebrates. FEBS letters 581, 5268-5274.

  • Miguel-Aliaga I and Thor S (2004)

    Segment-specific Prevention of Pioneer Neuron Apoptosis by Cell-autonomous, Postmitotic Hox Gene Activity. Development 131, 6093-6105.

  • Miguel-Aliaga I, Allan DW and Thor S (2004)

    Independent Roles of the dachshund and eyes absent Genes in BMP Signaling, Pathfinding and Neuropeptidergic Cell Specification. Development 131, 5837-5848.

  • Allan DW, St Pierre SE, Miguel-Aliaga I and Thor S (2003)

    Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code. Cell 113, 73-86. 

  • Chan YB, Miguel-Aliaga I, Franks C, Thomas N, Trulzsch B, Sattelle DB, Davies KE and van den Heuvel M (2003)

    Neuromuscular defects in a Drosophila survival motor neuron gene mutant. Human molecular genetics 12, 1367-1376.

  • Vargas JD, Culetto E, Ponting CP, Miguel-Aliaga I, Davies KE and Sattelle DB (2002)

    Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene. Mechanisms of development 117, 289-292.

  • Miguel-Aliaga I, Chan YB, Davies KE and van den Heuvel M (2000)

    Disruption of SMN function by ectopic expression of the human SMN gene in Drosophila. FEBS Letters 486, 99-102.

  • Miguel-Aliaga I, Culetto E, Walker DS, Baylis HA, Sattelle DB and Davies KE (1999)

    The Caenorhabditis elegans orthologue of the human gene responsible for spinal muscular atrophy is a maternal product critical for germline maturation and embryonic viability. Human molecular genetics 8, 2133-2143.

  • Talbot K, Miguel-Aliaga I, Mohaghegh P, Ponting CP and Davies KE (1998)

    Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complex. Human molecular genetics 7, 2149-2156.